The Antihistamine Drugs

Effects of two antihistamine drugs on actual driving performance.

A double blind placebo controlled experiment was conducted measuring the effects of the centrally active antihistamine triprolidine and the peripherally acting antihistamine terfenadine on actual driving performance in a group of experienced women drivers. Triprolidine greatly impaired driving behaviour, whereas terfenadine did not. Triprolidine also impaired subjective and objective measures o...

Antihistamine Toxicosis

Antihistamines are H1-receptor antagonists widely used in human and veterinary medicine to provide symptomatic relief of allergic signs caused by histamine release, including pruritus and anaphylactic reactions. Antihistamines are also commonly used as sedatives and antiemetics. 1 Antihistamines can be divided into first and second-generation (also called nonsedating) agents (Table 1). First-ge...

Antihistamine use in children.

This review provides an overview of the use of antihistamines in children. We discuss types of histamine receptors and their mechanism of action, absorption, onset and duration of action of first-generation and second-generation H(1)-antihistamines, as well as elimination of H(1)-antihistamines which has important implications for dosing in children. The rationale for the use of H(1)-antihistam...

Histamine and antihistamine substances.

Non-sedating antihistamine drugs and cardiac arrhythmias -- biased risk estimates from spontaneous reporting systems?

AIMS This study used spontaneous reports of adverse events to estimate the risk for developing cardiac arrhythmias due to the systemic use of non-sedating antihistamine drugs and compared the risk estimate before and after the regulatory action to recall the over-the-counter status of some of these drugs. METHODS All suspected adverse drug reactions (ADRs) reported until July 1999 to the Neth...